Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation
Hippo信号通路在齐卡病毒复制和神经炎症的发病中具有关键作用
作者: Gustavo GarciaSayan PaulSara BesharaV. Krishnan RamanujanArunachalam RamaiahKarin Nielsen-SainesMelody M.H. LiSamuel W. FrenchKouki MorizonoAshok KumarVaithilingaraja Arumugaswami
作者单位: 1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California
2Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California
3Department of Pathology and Laboratory Medicine, University of California, Los Angeles, California
4Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California
5Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California
6UCLA AIDS Institute, David Geffen School of Medicine, University of California, Los Angeles, California
7Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California
8Department of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, India
9Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California
10Department of Ecology and Evolutionary Biology, University of California, Irvine, California
11Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, Michigan
刊名: The American Journal of Pathology, 2020, Vol.190 (4), pp.844-861
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2019.12.005
英文摘要: Zika virus (ZIKV) is a reemerging human pathogen that causes congenital abnormalities, including microcephaly and eye disease. The cellular/molecular basis of ZIKV and host interactions inducing ocular and neuronal pathogenesis are unclear. Herein, we noted that the Hippo/Salvador-Warts-Hippo signaling pathway, which controls organ size through progenitor cell proliferation and differentiation, is dysregulated after ZIKV infection. In human fetal retinal pigment epithelial cells, there is an early induction of transcriptional coactivator, Yes-associated protein (YAP), which is later degraded with a corresponding activation of the TANK binding kinase 1/interferon regulatory factor 3 type I interferon pathway. YAP/transcriptional co-activator with a PDZ-binding domain (TAZ) silencing...
全文获取路径: Elsevier  (合作)
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影响因子:4.522 (2012)

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