CCR5 and CXCL12 allelic variants: Possible association with childhood neuroblastoma susceptibility?
CCR5和CXCL12等位变异:可能与儿童神经母细胞瘤易感性有关?
作者: Daniel Rubens Marques Vieira-FilhoMarla Karine AmaranteCyntia Mayumi IshibashiCarolina Batista ArizaGlauco Akelinghton Freire VitielloKaren Brajão de OliveiraRoberta Losi GuembarovskiMaria Angelica Ehara Watanabe
作者单位: 1Department of Pediatrics and Pediatric Surgery, Health Sciences Center, Londrina State University, Londrina, PR, Brazil
2Laboratory of DNA Polymorphisms and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR, Brazil
3Department of General Biology, Biological Sciences Center, Londrina State University, Londrina, PR, Brazil
4Philadelphia University Center, Londrina, PR, Brazil
5Laboratory of Molecular Genetics and Immunology, Department of Pathological Sciences, Biological Sciences Center, Londrina State University, Londrina, PR, Brazil
刊名: Journal of Neuroimmunology, 2020, Vol.342
来源数据库: Elsevier Journal
DOI: 10.1016/j.jneuroim.2020.577193
关键词: NeuroblastomaCCR5CXCL12Genetic polymorphism
英文摘要: Abstract(#br)Neuroblastoma (NB) is a heterogeneous and particularly malignant childhood neoplasm in its higher stages, prone to form metastasis in selected organs and for which there is still no efficient treatment available beyond surgery. Evidence indicates that chemokines and their receptors present involvement as mediators of neuroinflammation and have a neurophysiological role. In the present study, we aimed to verify if CCR5 (rs333) and CXCL12 (rs1801157) allelic variants were associated with NB. For CCR5 (rs333) D32 carriers (OR: 5.96, IC: 2.21–16.06) and for CXCL12 genotype 3′A/3′A (OR:26.18, IC:6.15–111.4) there were statistically significant differences as well to allelic frequency (OR:4.20, IC: 2.19–8.03). Although no correlation was verified regarding prognostic parameters for...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:3.033 (2012)

×
关键词翻译
关键词翻译
  • susceptibility 磁化率
  • allelic 等位的
  • neuroblastoma 成神经细胞瘤
  • CCR Carriage Control Register
  • childhood 幼年
  • association 联合
  • polymorphism 多晶形