The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats
黑种草提取物对脂多糖诱导的大鼠肺炎症及氧化应激的保护作用
作者: Amin Mokhtari-ZaerFatemeh NorouziVahid Reza AskariMohammad Reza KhazdairNama Mohammadian RoshanMostafa BoskabadyMahmoud HosseiniMohammad Hossein Boskabady
作者单位: 1Pharmaceutical Sciences Research Center, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
2Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran
5Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
7Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
刊名: Journal of Ethnopharmacology, 2020, Vol.253
来源数据库: Elsevier Journal
DOI: 10.1016/j.jep.2020.112653
关键词: Nigella sativaLung injuryLPSInflammationOxidative stress
英文摘要: Abstract(#br)Ethnopharmacological relevance(#br)Oxidative stress during inflammation can increase inflammation and damage tissue. Nigella sativa L. (NS) showed many pharmacological properties including antioxidant and anti-inflammatory activities.(#br)Aim of the study: In this study, the preventive effect of NS on lung inflammation and oxidative stress induced by lipopolysaccharide (LPS) in the rats was investigated.(#br)Materials and methods(#br)Male rats were assigned to: Control, LPS (1 mg/kg, i.p.), LPS + NS (100, 200, 400 mg/kg, i.p.), (10 per group). Saline (1 ml/kg) was intra-peritoneal (i.p.) injected instead of LPS in the rats of the control group. LPS dissolved in saline and injected i.p. daily for 14 days. Treatment with NS extracts started two days before LPS administration...
全文获取路径: Elsevier  (合作)
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影响因子:2.755 (2012)

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关键词翻译
关键词翻译
  • sativa 漂白亚麻纤维卷
  • inflammation 炎症
  • stress 应力
  • induced 感应的
  • effect 效应
  • oxidative 氧化的
  • extract 提取
  • protective 保护的