Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways
组蛋白去乙酰化酶抑制剂Pracinostat ( SB939 )通过激活IL-6 / STAT3信号通路抑制乳腺癌转移和生长
作者: Jing ChenNa LiBoxia LiuJun LingWenjun YangXiufeng PangTao Li
作者单位: 1School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China
2Key Laboratory of Fertility Preservation and Maintenance (Ningxia Medical University), Ministry of Education, Yinchuan 750004, China
3Center for neurological diseases, The First People's Hospital of Shizuishan, Shizuishan 753200, China
4Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
5Department of Oncology, General Hospital of the Ningxia Medical University, Yinchuan 750004, China
刊名: Life Sciences, 2020, Vol.248
来源数据库: Elsevier Journal
DOI: 10.1016/j.lfs.2020.117469
关键词: HDACsSB939Breast cancerEMTTumor metastasis
英文摘要: Abstract(#br)Aims(#br)Histone deacetylases inhibitors have shown favorable antitumor activity in clinical investigations. In the present study, we assessed the effects of a novel hydroxamic acid-based HDAC inhibitor, SB939, on breast cancer metastasis and tumor growth and characterized the underlying molecular mechanisms.(#br)Main methods(#br)MTS, Wound-healing, and Transwell chamber invasion assays were used to detect the inhibition effects of SB939 on proliferation, migration, and invasion of breast cancer cells. Western blot, cellular immunofluorescence, and EMSA were used to explore the molecular mechanism of SB939 in suppressing breast cancer metastasis. MDA-MB-231 subcutaneous tumor-bearing model of nude mice and the spontaneous metastasis model of breast cancer were both applied to...
全文获取路径: Elsevier  (合作)
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影响因子:2.555 (2012)

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关键词翻译
关键词翻译
  • metastasis 同质蜕变
  • deacetylase 脱乙酰基酶
  • inactivating 钝化
  • breast 胸部
  • STAT 静止的
  • signalling 发信号
  • histone 组蛋白
  • cancer 癌症
  • EMT EMergency Treatment
  • growth 生长