The impact of multiple sclerosis relapses on worsening over the long term; insights in the treatment era
作者: Thomas F. ScottNicholas Bertha
作者单位: 1Department of Neurology and Neuroscience Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, United States of America
2Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, United States of America
3Pennsylvania State College of Medicine, Hershey, PA, United States of America
刊名: Journal of the Neurological Sciences, 2020, Vol.413
来源数据库: Elsevier Journal
DOI: 10.1016/j.jns.2020.116773
关键词: Multiple sclerosisRelapseProgressionNatural historyMRI
英文摘要: Abstract(#br)Relapses of multiple sclerosis (MS) are the clinical manifestations of inflammatory events involving eloquent anatomical structures within the central nervous system. Relapses are associated with worsening disability of MS patients in both early and later disease, even after progressive features are seen. The impact of relapses on the long-term course of the disease is now being realized as a generation of treated patients is now elderly. New MRI brain lesions can be viewed as a radiologic manifestation of acute inflammation and are associated with similar prognostic value. The complex relationship between clinical relapse activity and later slow progressive worsening remains incompletely understood, however, there is increasing biological plausibility for a causative...
全文获取路径: Elsevier  (合作)
影响因子:2.243 (2012)

  • sclerosis 硬化
  • treatment 处理
  • history 历史
  • impact 冲击碰撞
  • multiple 多次的
  • MRI Machine-Readable Information
  • over 在上方