Lower Small-Worldness of Intrinsic Brain Networks Facilitates the Cognitive Protection of Intellectual Engagement in Elderly People Without Dementia: A Near-Infrared Spectroscopy Study
作者: Jing WangYue GuWentian DongMei ZhaoJu TianTingting SunXin YuGaoxiang OuyangHuali Wang
作者单位: 1Peking University Institute of Mental Health (Sixth Hospital) (JW, WD, MZ, JT, TS, XY, HW), Beijing, China
2National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health (Peking University) (JW, WD, MZ, JT, TS, XY HW), Beijing, China
3Beijing Municipal Key Laboratory for Translational Research on Diagnosis and Treatment of Dementia (JW, MZ, TS, XY, HW), Beijing, China
4Key Laboratory of Computer Vision and System (Ministry of Education), School of Computer Science and Engineering, Tianjin University of Technology (YG), Tianjin, China
5Department of Psychiatry, University of Melbourne (MZ), Melbourne, Australia
6State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University (GO), Beijing, China
刊名: The American Journal of Geriatric Psychiatry, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.jagp.2020.02.006
关键词: Intrinsic functional networksCognitionIntellectual engagementElderly people
原始语种摘要: Abstract(#br)Objective(#br)Lifetime intellectual engagement may be associated with cognitive ability late in life. However, the current evidence on whether cognitive activities will improve and/or maintain cognitive function is heterogeneous. Drawing on knowledge of the brain's intrinsic small-world organization which combines regional specialization and efficient global information transfer, we aimed to explore that whether individual differences in the small-worldness of resting-state functional connectivity (rsFC) networks would explain the variability in the strength of the association between intellectual engagement and cognitive functioning.(#br)Methods(#br)Sixty-five elderly people without dementia were enrolled and scanned with a 52-channel near-infrared spectroscopy system. The...
全文获取路径: Elsevier  (合作)
影响因子:4.131 (2012)

  • engagement 啮合
  • intellectual 知识分子
  • elderly 上了年纪的
  • cognitive 修]认知[识
  • bilateral 双边的
  • cognition 认识
  • maintain 
  • functional 功能的
  • individual 个体
  • small 小的