Long Non-coding RNA LOXL1-AS1 Drives Breast Cancer Invasion and Metastasis by Antagonizing miR-708-5p Expression and Activity
长非编码RNA LOXL1 - AS1通过拮抗miR-708 - 5p的表达和活性来驱动乳腺癌的侵袭和转移
作者: Hui-ting DongQun LiuTingting ZhaoFan YaoYingying XuBo ChenYunfei WuXinyu ZhengFeng JinJiguang LiPeng Xing
作者单位: 1Department of Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang, China
刊名: Molecular Therapy - Nucleic Acids, 2020, Vol.19 , pp.696-705
来源数据库: Elsevier Journal
DOI: 10.1016/j.omtn.2019.12.016
关键词: Breast cancerLOXL1-AS1MetastasisMiR-708-5pStability
原始语种摘要: LOXL1-AS1, a recently characterized long non-coding RNA (lncRNA), has been reported to modulate tumor progression in several types of cancer. However, the expression and role of LOXL1-AS1 in breast cancer remain unclear. In this study, we sought to identify novel lncRNA regulators engaged in breast cancer metastasis. To this end, we examined 42 cancer-related lncRNAs between MCF7 (with low metastatic potential) and MDA-MB-231 (with high metastatic potential) cells. These lncRNAs have been found to affect the invasiveness of several cancer types, but they are still undefined in breast cancer. Among the 42 candidates, LOXL1-AS1 is significantly increased in MDA-MB-231 cells relative to MCF7 cells. We also show that LOXL1-AS1 is upregulated in breast cancer tissues and cells compared to...
全文获取路径: Elsevier  (合作)

  • breast 胸部
  • potential 
  • cancer 癌症
  • metastasis 同质蜕变
  • coding 编码
  • invasiveness 侵入力
  • correlated 相关
  • therapeutic 治疗的
  • expression 表示