Precision medicine in the care of rheumatoid arthritis: Focus on prediction and prevention of future clinically-apparent disease
作者: Michael MahlerLaura Martinez-PratJeffrey A. SparksKevin D. Deane
作者单位: 1Inova Diagnostics, Inc., San Diego, CA, USA
2Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
3University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
刊名: Autoimmunity Reviews, 2020, Vol.19 (5)
来源数据库: Elsevier Journal
DOI: 10.1016/j.autrev.2020.102506
关键词: Rheumatoid arthritisAutoantibodiesPredictionPreventionTreatmentRisk factors
英文摘要: Abstract(#br)There is an emerging understanding that an individual's risk for future rheumatoid arthritis (RA) can be determined using a combination of factors while they are still in a state where clinically-apparent inflammatory arthritis (IA) is not yet present. Indeed, this concept has underpinned several completed and ongoing prevention trials in RA. Importantly, risk factors can be divided into modifiable (e.g. smoking, exercise, dental care and diet) and non-modifiable factors (e.g. genetics, sex, age). In addition, there are now several biomarkers including autoantibodies, inflammatory markers and imaging techniques that are highly predictive of future clinically-apparent IA/RA. Although none of the prevention studies have yet provided major breakthroughs, several of them have...
全文获取路径: Elsevier  (合作)
影响因子:7.975 (2012)

  • arthritis 关节炎
  • rheumatoid 患风湿病的
  • prevention 妨碍
  • medicine 
  • clinically 临床上
  • future 将来
  • apparent 外观上的
  • prediction 预报
  • disease 
  • Focus 焦点