Synthesis of gold nanoflowers stabilized with amphiphilic daptomycin for enhanced photothermal antitumor and antibacterial effects
作者: Jing WangJin ZhangKai LiuJinfeng HeYongqiang ZhangShengfu ChenGuanglong MaYanshuai CuiLonggang WangDawei Gao
作者单位: 1State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China
2College of Chemistry and Environmental Engineering, Shanxi Datong University, Datong 037009, China
3Key Laboratory of Applied Chemistry, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, China
4Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, China
刊名: International Journal of Pharmaceutics, 2020, Vol.580
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2020.119231
关键词: Gold nanoflowerDaptomycinPhotothermalAntitumorAntibacterialBiomineralization
原始语种摘要: Abstract(#br)The development of effective agents for cancer therapy and inhibition of bacterial infection has drawn a great deal of interest. Photothermal therapy has been widely used for the thermal ablation of tumor cells. In addition, antibiotics have the ability to inhibit the growth of bacteria. Thus, the combination of photothermal therapy and antibiotics may be one of the methods to address the problem. Herein, it is the first time that daptomycin (Dap) micelles were used as the template and reducing agents to prepare stable daptomycin-gold nanoflowers (Dap-Au n NFs) under mild conditions. The energy dispersive spectrometer (EDS) spectrum and X-ray diffraction (XRD) spectrum indicated that Dap-Au n NFs were successfully prepared. When the molar ratio of HAuCl 4 to Dap was 6, the...
全文获取路径: Elsevier  (合作)
影响因子:3.458 (2012)

  • stabilized 稳定的
  • amphiphilic 两亲的
  • antitumor 抗癌的
  • antibacterial 抗细菌的
  • effects 海员自身物品
  • enhanced 增强