Relationships between visceral/subcutaneous adipose tissue FABP4 expression and coronary atherosclerosis in patients with metabolic syndrome
作者: Selcuk GormezRefik ErdimGokce AkanBarıs CaynakCihan DuranDemet GunayVolkan SozerFatmahan Atalar
作者单位: 1Department of Cardiology, Acibadem Mehmet Ali Aydinlar University, Faculty of Medicine, Istanbul, Turkey
2Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
3MUHAS Genetics Laboratory, MUHAS, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania
4Department of Cardiovascular Surgery, Istanbul Bilim University, Istanbul, Turkey
5Department of Radiology, Istanbul Bilim University, Istanbul, Turkey
6Sisli Florence Nightingale Hospital, Department of Biochemistry, Istanbul, Turkey
7Department of Biochemistry, Yildiz Technical University, Istanbul, Turkey
8Department of Medical Genetics, Child Health Institute, Istanbul University, Istanbul, Turkey
刊名: Cardiovascular Pathology, 2020, Vol.46
来源数据库: Elsevier Journal
DOI: 10.1016/j.carpath.2019.107192
关键词: Coronary atherosclerosisFatty acid-binding protein 4Epicardial adipose tissueEpicardial adipose tissue volumeMetabolic syndromeSingle nucleotide polymorphism
英文摘要: Abstract(#br)Background(#br)Cytoplasmic fatty acid-binding proteins facilitate the transport of lipids to specific compartments in cells. Fatty acid-binding protein 4 (FABP4), also known as aP2 or A-FABP, plays a key role in the development of atherosclerosis, insulin resistance, obesity, and metabolic syndrome (MS). The FABP4 polymorphisms are associated with protein expression changes in vitro and metabolic and vascular alterations in vivo . The aim of this study was to investigate the association between FABP4 messenger ribonucleic acid (mRNA) expression levels in epicardial (EAT), pericardial (PAT), and subcutaneous adipose tissues (SAT), and the extent of coronary atherosclerosis in coronary artery disease (CAD) patients with MS. Furthermore, the relationship between the extent of...
全文获取路径: Elsevier  (合作)
影响因子:2.352 (2012)

  • subcutaneous 皮下的
  • adipose 脂肪的
  • visceral 内脏的
  • coronary 冠状的
  • metabolic 新陈代谢的
  • expression 表示
  • syndrome 症候群
  • tissue 组织
  • between 在中间