N-myc downstream-regulated gene 2 deficiency aggravates memory impairment in Alzheimer's disease
作者: Liang TaoYuanyuan ZhuRui WangJiao HanYulong MaHang GuoWenhong TangLixia ZhuoZe FanAnqi YinWugang HouYan Li
作者单位: 1Center for Brain Science & Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China
2Department of Anesthesiology and Perioperative Medicine, Xijing Hospital of The Fourth Military Medical University, Xi’an, China
3Department of Neurobiology, The Fourth Military Medical University, Xi’an, China
4Anesthesia and Operation Center, The First Medical Center to Chinese PLA General Hospital, Beijing, China
5Department of Anesthesiology, The Seventh Medical Center to Chinese PLA General Hospital, Beijing, China
6Department of Anesthesiology, the 960th Hospital of PLA, Jinan, China
刊名: Behavioural Brain Research, 2020, Vol.379
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbr.2019.112384
关键词: NDRG2Alzheimer's disease (AD)Memory impairmentNovel object recognition
原始语种摘要: Abstract(#br)Alzheimer's disease (AD) is a chronic degenerative disease of the central nervous system and the most common dementia type in elderly people. N-myc downstream-regulated gene 2 (NDRG2 ), a cell stress response gene, is primarily expressed in astrocytes in mammalian brains. The hippocampal protein levels of NDRG2 in AD patients were significantly higher than those in healthy peers. However, whether the increase in NDRG2 is involved in the development of AD or is an endogenous protective response initiated by stress remains unknown. Here, we investigated the roles of NDRG2 in the development of memory impairment in AD using mouse models established by amyloid β injection or crossing of APP/PS1 mice. We found that NDRG2 deficiency worsened the memory impairment in AD mice. In...
全文获取路径: Elsevier  (合作)
影响因子:3.327 (2012)

  • impairment 减损
  • memory 记忆
  • myc 真菌
  • regulated 规定
  • downstream 顺聊
  • disease 
  • dementia 痴呆
  • endogenous 内成的
  • brains 智力
  • degenerative 退化的