MiR-3940-5p promotes granulosa cell proliferation through targeting KCNA5 in polycystic ovarian syndrome
作者: Ling GaoDandan WuYanting WuZuwei YangJianzhong ShengXianhua LinHefeng Huang
作者单位: 1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China
2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, China
3Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, 310058, China
刊名: Biochemical and Biophysical Research Communications, 2020, Vol.524 (4), pp.791-797
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2020.01.046
关键词: Cell proliferationMicroRNAPolycystic ovary syndromeGranulosa cell
英文摘要: Abstract(#br)Increased granulosa cell (GC) proliferation may contribute to abnormal folliculogenesis in patients with polycystic ovary syndrome (PCOS), which affects approximately 10% reproductive aged women. However, the mechanisms underlying increased GC proliferation in PCOS remain incompletely understood. In this study, we identified miR-3940-5p as a hub miRNA in GC from PCOS using weighted gene co-expression network analysis (WGCNA), and real-time polymerase chain reaction (RT-PCR) analysis confirmed that miR-3940-5p was significantly increased in GC from PCOS. Enrichment analysis of predicted target genes of miR-3940-5p indicated potential roles of miR-3940-5p in follicular development and cell proliferation regulation. Consistently, functional study confirmed that miR-3940-5p...
全文获取路径: Elsevier  (合作)

  • polycystic 多室的
  • targeting 导向目标
  • ovarian 卵巢的
  • granulosa 肉芽肿
  • syndrome 症候群
  • proliferation 增生
  • through 经过