Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress
作者: Hao WuYing WangYupeng ZhangFeng XuJiepeng ChenLili DuanTingting ZhangJian WangFengjiao Zhang
作者单位: 1Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China
2Sungen Biotech Co., Ltd, Shantou, 515000, PR China
3Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China
刊名: Redox Biology, 2020, Vol.32
来源数据库: Elsevier Journal
DOI: 10.1016/j.redox.2020.101500
关键词: NattokinaseTRL4NOX2InflammationOxidative stressThrombus
原始语种摘要: Abstract(#br)Thrombosis is a principle cause of cardiovascular disease, the leading cause of morbidity and mortality worldwide; however, the conventional anti-thrombotic approach often leads to bleeding complications despite extensive clinical management and monitoring. In view of the intense crosstalk between inflammation and coagulation, plus the contributing role of ROS to both inflammation and coagulation, it is highly desirable to develop safer anti-thrombotic agent with preserved anti-inflammatory and anti-oxidative stress activities. Nattokinase (NK) possesses many beneficial effects on cardiovascular system due to its strong thrombolytic and anticoagulant activities. Herein, we demonstrated that NK not only effectively prevented xylene-induced ear oedema in mice, but also...
全文获取路径: Elsevier  (合作)

  • inflammation 炎症
  • inhibiting 抑制
  • oxidative 氧化的
  • stress 应力
  • induced 感应的
  • coagulation 凝聚
  • novel 长篇小说
  • vicious 不道德的
  • insight 识别力
  • LPS Laboratory Peripheral System