Modulation of P2Y11-related purinergic signaling in inflammation and cardio-metabolic diseases
作者: Maria-Daniela DănilăMarie PiolletOana-Maria AburelDenis AngoulvantClaudie LefortStéphanie ChadetSebastien RogerMirela-Danina MunteanFabrice Ivanes
作者单位: 1Department of Functional Sciences - Pathophysiology, "Victor Babeș” University of Medicine and Pharmacy Timișoara, Romania
2Center for Translational Research and Systems Medicine, "Victor Babeș” University of Medicine and Pharmacy Timișoara, Romania
3EA4245 Transplantation Immunity Inflammation, Faculty of Medicine – Tours University& Loire Valley Cardiovascular Collaboration, Tours, F37000, France
4Cardiology Department, Trousseau Hospital, CHRU de Tours, F37000, Tours, France
刊名: European Journal of Pharmacology, 2020, Vol.876
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejphar.2020.173060
关键词: P2Y11 purinergic receptorCardio-metabolic diseasesInflammationCardioprotective agents
原始语种摘要: Abstract(#br)Chronic inflammation is the hallmark of cardiovascular pathologies with a major role in both disease progression and occurrence of long-term complications. The massive release of ATP during the inflammatory process activates various purinergic receptors, including P2Y11. This receptor is less studied but ubiquitously expressed in all cells relevant for cardiovascular pathology: cardiomyocytes, fibroblasts, endothelial and immune cells. While several studies suggested a potential pro-inflammatory role for P2Y11 receptors, recent literature data are supportive of an anti-inflammatory profile characterized by the immunosuppression of dendritic cells, inhibition of fibroblast proliferation and of cytokines and ATP secretion. Moreover, modulation of its activity appears to mediate...
全文获取路径: Elsevier  (合作)
影响因子:2.592 (2012)

  • inflammation 炎症
  • cardio 
  • signaling 发信号
  • related 有关的
  • metabolic 新陈代谢的