The cytosolic isoform of glutaredoxin 2 promotes cell migration and invasion
作者: Manuela GellertErik RichterJörg MostertzLiane KantzKai MasurEva-Maria HanschmannSilvia RibbackNils KroegerElke SchaeffelerStefan WinterFalko HochgräfeMatthias SchwabChristopher Horst Lillig
作者单位: 1Institute for Medical Biochemistry and Molecular Biology, University Medicine, University Greifswald, Germany
2Competence Center Functional Genomics, Junior Research Group Pathoproteomics, University Greifswald, Germany
3Center for Innovation Competence plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Greifswald, Germany
4Institute for Pathology, Germany
5Clinic for Urology, University Medicine Greifswald, Germany
6Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
7University of Tuebingen, Tuebingen, Germany
8Departments of Clinical Pharmacology, and Pharmacy and Biochemistry, University of Tuebingen, Tuebingen, Germany
刊名: BBA - General Subjects, 2020, Vol.1864 (7)
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbagen.2020.129599
关键词: GlutaredoxinRedox regulationCell motilityInvasiveness
英文摘要: Abstract(#br)Backround(#br)Cytosolic glutaredoxin 2 (Grx2c) controls axonal outgrowth and is specifically induced in many cancer cell lines. We thus hypothesized that Grx2c promotes cell motility and invasiveness.(#br)Methods(#br)We characterized the impact of Grx2c expression in cell culture models. We combined stable isotope labeling, phosphopeptide enrichment, and high-accuracy mass spectrometry to characterize the underlying mechanisms.(#br)Results(#br)The most prominent associations were found with actin dynamics, cellular adhesion, and receptor-mediated signal transduction, processes that are crucial for cell motility. For instance, collapsin response mediator protein 2, a protein involved in the regulation of cytoskeletal dynamics, is regulated by Grx2c through a redox switch that...
全文获取路径: Elsevier  (合作)

  • migration 迁移
  • motility 游动性
  • invasion 侵入
  • regulation