Are polyploid giant cancer cells in high grade serous carcinoma of the ovary blastomere-like cancer stem cells?
是卵巢爆裂样癌干细胞高级别浆液性癌中的多倍体巨细胞?
作者: Alireza SalemKaren PintoMeghan KochJinsong LiuElvio G. Silva
作者单位: 1Baylor University Medical Center, Department of Pathology, 3600 Gaston Avenue, Dallas, TX 75246, United States of America
2University of Texas MD Anderson Cancer Center, Department of Pathology, 1515 Holcombe Blvd. Unit 0072, Houston, TX 77030, United States of America
刊名: Annals of Diagnostic Pathology, 2020, Vol.46
来源数据库: Elsevier Journal
DOI: 10.1016/j.anndiagpath.2020.151505
关键词: OvaryHigh grade serous carcinomaPolyploid giant cancer cellsMultinucleated and giant tumor cellsEndoreplicationBlastomere-like cancer stem cells
英文摘要: Abstract(#br)Polyploid giant cancer cells, either multinucleated or mononucleated, in high grade serous carcinoma of the ovary have been previously recognized. Different theories including degenerative changes or an important step in the development of high grade serous carcinoma have been proposed. Here we investigate possible explanations for the presence of polyploid giant cancer cells in high grade serous carcinoma. We reviewed 33 cases of ovarian high grade serous carcinoma (12 stage I, 7 stage II, and 14 stage III). We counted the number of polyploid giant cancer cells in 20 consecutive 10× fields. In 11 cases where polyploid giant cancer cells were easily found, immunohistochemistry for Ki67, p53, and OCT 3/4 was performed. Patients with polyploid giant cancer cells were older than...
全文获取路径: Elsevier  (合作)
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影响因子:0.975 (2012)

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关键词翻译
关键词翻译
  • serous 浆液的
  • cells 麻风细胞
  • blastomere 分裂球
  • ovary 子房
  • carcinoma 癌症
  • grade 品位
  • cancer 癌症
  • giant 巨大的
  • polyploid 多倍体
  • tumor 肿胀