Hypoxia upregulates Cxcl12 in hepatocytes by a complex mechanism involving hypoxia-inducible factors and transforming growth factor-β
作者: Jenna StricklandDomonique GarrisonBryan L. Copple
作者单位: 1Department of Pharmacology and Toxicology and the Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States
刊名: Cytokine, 2020, Vol.127
来源数据库: Elsevier Journal
DOI: 10.1016/j.cyto.2020.154986
关键词: Cxcl12HypoxiaTGF-βFibrosisLiverHepatocytes
英文摘要: Abstract(#br)Introduction(#br)Cxcl12, or stromal-derived factor-1, is a chemokine produced by several hepatic cell types, including hepatocytes, after liver injury and surgical resection. Studies have revealed that Cxcl12 is important for regeneration of the liver after surgical resection and for development of liver fibrosis during chronic liver injury. While the function of Cxcl12 in the liver is well established, the mechanism by which Cxcl12 is upregulated is not fully understood. Because regions of hypoxia develop in the liver following injury, we tested the hypothesis that hypoxia upregulates Cxcl12 in hepatocytes by a hypoxia-inducible factor (HIF)-dependent mechanism.(#br)Methods(#br)To test this hypothesis, primary mouse hepatocytes were isolated from the livers of...
全文获取路径: Elsevier  (合作)
影响因子:2.518 (2012)

  • hypoxia 氧过少
  • transforming 变换
  • inducible 可归纳的
  • complex 超群
  • factor 因素
  • growth 生长
  • mechanism 机构