Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression
p H可转换胶束经皮给药具有靶向作用的siRNA可抑制皮肤黑色素瘤进展
作者: Mao-Ze WangJie NiuHui-Jian MaHaseeb Anwar DadHai-Tao ShaoTie-Jun YuanLi-Hua Peng
作者单位: 1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China
2State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, PR China
刊名: Journal of Controlled Release, 2020, Vol.322 , pp.95-107
来源数据库: Elsevier Journal
DOI: 10.1016/j.jconrel.2020.03.023
关键词: Cationic micellesTransdermal deliveryTumor targetingPH triggered releaseSiRNASkin melanoma
英文摘要: Abstract(#br)Melanoma is an aggressive disease with rapid progression and fast relapse, representing one of the formidable challenges in clinic. Current systemic therapies for melanoma exhibit limited anticancer potential due to the lack of specificity and limited efficacy. Herein, we design a cationic polymer (SCP-HA-PAE) by conjugating skin/cell penetrating peptide (SCP) and hyaluronic acid (HA) to the amphipathic polymer (poly β-amino esters, PAE), then fabricate the nanocarriers (SHP) composed by SCP-HA-PAE for delivering siRNA to skin melanoma by transdermal application. SHP not only manifests the excellent ability in penetrating through skin stratum corneum (SC), targeting melanoma and being sensitive to pH, but also expresses the advantages in compacting the vector/siRNAs...
全文获取路径: Elsevier  (合作)
影响因子:7.633 (2012)

  • targeting 导向目标
  • melanoma 黑瘤
  • delivery 移交
  • progression 级数
  • suppress 扼止
  • switchable 可变换的
  • effect 效应
  • triggered 触发的
  • Skin 皮肤
  • release 释放