Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation
作者: Javaria MunirTrinh Van NguPenchatr Diskul Na AyudthayaSeongho Ryu
作者单位: 1Soonchunhyang Institute of Medi-bioscience (SIMS), Soonchunhyang University, Cheonan, South Korea
2Department of Integrated Biomedicine, Soonchunhyang University, Cheonan, South Korea
3Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand
刊名: Biochemical and Biophysical Research Communications, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2020.03.064
关键词: Breast cancerProliferationInvasionMigrationGlypican-4Tumor suppressor
英文摘要: Abstract(#br)Glypican-4 (GPC-4) is a heparan sulphate glycoprotein, associated with cell membrane via a Glycosyl phosphatidyl (GPI)-anchor. It is involved in cell migration, cell growth, differentiation and morphogenesis as well as chemoresistance and cancer stem cell maintenance in pancreatic cancer. However, its role in breast cancer remains unclear. To elucidate the role of GPC-4 in breast cancer, we analyzed GPC-4 expression in breast cancer patients and breast cancer cell lines. Our results demonstrated that GPC-4 expression was downregulated in metastatic tumors as compared to non-metastatic tumors. Further, GPC4’s downregulation was confirmed in breast cancer metastatic cells (MDA-MBA-231 and MDA-MB-LM2) compared to non-metastatic cells (T47-D and MCF-7) with quantitative PCR and...
全文获取路径: Elsevier  (合作)

  • migration 迁移
  • breast 胸部
  • inducing 施感的
  • progression 级数
  • cancer 癌症
  • proliferation 增生