Comparison of intramuscular and intravenous pharmacokinetics of ginsenosides in humans after dosing XueShuanTong, a lyophilized extract of Panax notoginseng roots
作者: Hai-Yan ZhangWei NiuOlajide E. OlaleyeFei-Fei DuFeng-Qing WangYu-Hong HuangLei YuanYan-Fen LiGuan-Ping LiuFang XuJun-Ling YangChuan Li
作者单位: 1Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China
2State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China
3Second Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, China
4Idorsia (Shanghai) Pharmaceuticals Co., Ltd., Shanghai, 201203, China
5Guangxi Wuzhou Pharmaceutical (Group) Co., Ltd, Wuzhou, Guangxi Zhuang Autonomous Region, 543000, China
刊名: Journal of Ethnopharmacology, 2020, Vol.253
来源数据库: Elsevier Journal
DOI: 10.1016/j.jep.2020.112658
关键词: GinsenosidePharmacokineticsIntramuscularIntravascularXueShuanTongPanax notoginseng rootsSanqi
英文摘要: Abstract(#br)Ethnopharmacological relevance(#br)Many bioactive constituents of Chinese herbal medicines have poor oral bioavailability. Besides oral administration, herbal medicines in China are also prepared for parenteral administration. Unlike for intravenous route, little is known about the intramuscular pharmacokinetics of herbal compounds. To facilitate rational use of herbal medicine, it is important to better understand such intramuscular pharmacokinetics.(#br)Aim of the study(#br)Bioactive constituents of XueShuanTong (a lyophilized extract of Panax notoginseng roots, extensively used in treatment of ischemic heart and cerebrovascular diseases) predominantly comprise ginsenosides Rb 1 and Rd of 20( S )-protopanaxadiol-type and ginsenosides Rg 1 , and Re, and notoginsenoside R 1...
全文获取路径: Elsevier  (合作)
影响因子:2.755 (2012)

  • dosing 配量
  • intramuscular 肌肉内的
  • extract 提取
  • intravenous 静脉内的
  • after 在之后
  • roots 麻根