Cyclic adenosine monophosphate in acute ischemic stroke: some to update, more to explore
作者: Meiying XinJiachun FengYulei HaoJiulin YouXinyu WangXiang YinPei ShangDi Ma
作者单位: 1Department of Neurology, Jilin University First Hospital, Changchun, Jilin, China
刊名: Journal of the Neurological Sciences, 2020, Vol.413
来源数据库: Elsevier Journal
DOI: 10.1016/j.jns.2020.116775
关键词: Cyclic adenosine monophosphateIschemic strokePost-stroke neuroinflammationPeripheral immune system
原始语种摘要: Abstract(#br)The development of effective treatment for ischemic stroke, which is a common cause of morbidity and mortality worldwide, remains an unmet goal because the current first-line treatment management interventional therapy has a strict time window and serious complications. In recent years, a growing body of evidence has shown that the elevation of intracellular and extracellular cyclic adenosine monophosphate (cAMP) alleviates brain damage after ischemic stroke by attenuating neuroinflammation in the central nervous system and peripheral immune system. In the central nervous system, upregulated intracellular cAMP signaling can alleviate immune-mediated damage by restoring neuronal morphology and function, inhibiting microglia migration and activation, stabilizing the membrane...
全文获取路径: Elsevier  (合作)
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影响因子:2.243 (2012)

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关键词翻译
关键词翻译
  • stroke 笔划
  • monophosphate 单磷体
  • ischemic 福尔克曼氏麻痹
  • adenosine 腺苷
  • immune 免疫的
  • acute 急尖的
  • explore 勘探
  • system 
  • more 更多