P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway
作者: Shuai JiangYang GaoQi Hong YuMin LiXiang ChengShao Bo HuZi Fang SongQi Chang Zheng
作者单位: 1Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
刊名: Biochemical and Biophysical Research Communications, 2020
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2020.03.054
关键词: Photodynamic therapyTumor angiogenesisAnti-tumor therapyP-21-Activated kinase 1Hypoxia-inducible factor 1 alphaVascular endothelial growth factor
英文摘要: Abstract(#br)Photodynamic therapy (PDT) is an effective oncotherapy and has been approved for clinical application. Unfortunately, its therapeutic efficacy is usually overshadowed by tumor angiogenesis. Thus, a detailed understanding of the tumor angiogenesis upon PDT is imperative. This study aimed to investigate the potential contribution and mechanism of P-21-activated kinase 1 (PAK1) in PDT-induced tumor angiogenesis. Firstly, we found that PAK1 was upregulated upon PDT and associated with tumor angiogenesis. Then, we elucidated the underlying molecular mechanism. Activation of PAK1 prevents hypoxia-inducible factor 1 alpha (HIF-1α) protein from ubiquitin-mediated degradation. Thereafter, HIF-1α accumulation results in the upregulation of vascular endothelial growth factor (VEGF),...
全文获取路径: Elsevier  (合作)

  • angiogenesis 血管生成
  • photodynamic 在光中发荧光的
  • kinase 激酶
  • activated 激化了的
  • therapy 治疗
  • tumor 肿胀