Adjuvant therapy for early stage, endometrial cancer with lymphovascular space invasion: Is there a role for chemotherapy?
作者: Anna L. BeavisTing-Tai YenRebecca L. StoneStephanie L. WethingtonCaitlin CarrJi SonLaura ChambersChad M. MichenerStephanie RicciWesley C. BurkettDebra L. RichardsonAllison-Stuart StaleySusie AhnPaola A. GehrigDiogo TorresSean C. DowdyMackenzie W. SullivanSusan C. ModesittCatherine WatsonAshely VeadeJessie EhrismanLaura HavrileskyAngeles Alvarez SecordAmy LoreenKaitlyn GriffinAmanda JacksonAkila N. ViswanathanLeah R. JagerAmanda N. Fader
作者单位: 1The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2Department of Obstetrics and Gynecology, Cleveland Clinic, Cleveland, OH, USA
3Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
4Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA
5Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA
6Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, VA, USA
7Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
8Department of Obstetrics and Gynecology, University of Cincinnati Medical Center, Cincinnati, OH, USA
9Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
10Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
11Stephenson Cancer
刊名: Gynecologic Oncology, 2020, Vol.156 (3), pp.568-574
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygyno.2019.12.028
关键词: Lymphovascular space invasionUterine cancerEndometrial cancerChemotherapyRadiationAdjuvant treatment
原始语种摘要: Abstract(#br)Objectives(#br)Lymphovascular space invasion (LVSI) is an independent risk factor for recurrence and poor survival in early-stage endometrioid endometrial cancer (EEC), but optimal adjuvant treatment is unknown. We aimed to compare the survival of women with early-stage EEC with LVSI treated postoperatively with observation (OBS), radiation (RAD, external beam and/or vaginal brachytherapy), or chemotherapy (CHEMO)+/−RAD.(#br)Methods(#br)This was a multi-institutional, retrospective cohort study of women with stage I or II EEC with LVSI who underwent hysterectomy+/−lymphadenectomy from 2005 to 2015 and received OBS, RAD, or CHEMO+/−RAD postoperatively. Progression-free survival and overall survival were evaluated using Kaplan-Meier estimates and Cox proportional hazards...
全文获取路径: Elsevier  (合作)
影响因子:3.929 (2012)

  • chemotherapy 化学疗法
  • endometrial 子宫内膜的
  • invasion 侵入
  • cancer 癌症
  • there 那里
  • stage 
  • treatment 处理
  • early 
  • space 宇宙