Corticospinal inhibition and alexithymia in multiple sclerosis patients–An exploratory study
多发性硬化患者皮质脊髓抑制和述情障碍的探索性研究
作者: Moussa A. ChalahJean-Pascal LefaucheurAlain CréangeSamar S. Ayache
作者单位: 1EA 4391, Excitabilité Nerveuse et Thérapeutique, Université Paris-Est-Créteil, Créteil, France
2Service de Physiologie - Explorations Fonctionnelles, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France
3Service de Neurologie, Hôpital Henri Mondor, Assistance Publique - Hôpitaux de Paris, Créteil, France
刊名: Multiple Sclerosis and Related Disorders, 2020, Vol.41
来源数据库: Elsevier Journal
DOI: 10.1016/j.msard.2020.102039
关键词: Multiple sclerosisAlexithymiaToronto alexithymia scaleCortical silent periodCortical excitabilityTranscranial magnetic stimulation
原始语种摘要: Abstract(#br)Objectives(#br)Alexithymia is a multicomponent personality construct that could occur in up to 53% of patients with multiple sclerosis (MS), with recent works proposing higher rates of alexithymia in progressive MS. Among the available models of alexithymia, some propose a deficient interhemispheric communication and an aberrant GABAergic transmission at its origin. However, no single study has addressed the underlying physiological mechanisms of alexithymia in MS. The aim of this work was to assess the relationship between GABAergic neurotransmission and alexithymia in progressive MS by means of transcranial magnetic stimulation (TMS).(#br)Methods(#br)Twelve patients with high alexithymia and fifteen patients with low alexithymia were included based on Toronto Alexithymia...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • alexithymia 述情障碍
  • sclerosis 硬化
  • inhibition 抑制
  • stimulation 激励
  • silent 无声的
  • cortical 皮层的
  • excitability 兴奋性
  • comprehensive 全面
  • exploratory 勘探的
  • period