Arginine accelerates intestinal health through cytokines and intestinal microbiota
作者: Miaomiao WuHao XiaoFangyuan ShaoBie TanShenglan Hu
作者单位: 1State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, 1 Dafeng 1st Street, Guangzhou 510640, China
2Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA
3Faculty of Health Sciences, University of Macau, Macau
4Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, Hunan, China
刊名: International Immunopharmacology, 2020, Vol.81
来源数据库: Elsevier Journal
DOI: 10.1016/j.intimp.2019.106029
关键词: ArginineIntestinal microbiotaSecretory immunoglobulin AT cellsIntestinal immunity
英文摘要: Abstract(#br)Arginine supplementation improves intestinal damage and intestinal immunity, but the underlying mechanism of the effects of arginine supplementation on intestinal SIgA secretion is largely unknown. Therefore, this study was conducted to investigate the underlying pathway on the effects of arginine supplementation in secretory IgA (SIgA) production in mice. The results showed that 0.4% arginine supplementation promoted (P < 0.05) SIgA production in intestinal lumina and IgA + plasma cell numbers in the ileum of mouse. Arginine supplementation significantly increased (P < 0.05) cytokines expression in mouse ileal associated with T cell-dependent and T cell-independent pathways of SIgA induction, including IL-5, IL-6, IL-13, transforming growth factor (TGF-)β2, TGF-β3, TGF-βR2,...
全文获取路径: Elsevier  (合作)
影响因子:2.417 (2012)

  • microbiota 微生物区系
  • intestinal 肠的
  • cytokines 细胞浆移动
  • immunoglobulin 免疫球蛋白
  • immunity 免疫
  • health 保健
  • cells 麻风细胞
  • through 经过