Amentoflavone suppresses cell proliferation and induces cell death through triggering autophagy-dependent ferroptosis in human glioma
门冬氨酸通过诱导脑胶质瘤细胞自噬依赖性铁下垂抑制细胞增殖和诱导细胞死亡
作者: Yan ChenNing LiHaijing WangNingning WangHui PengJing WangYihong LiMingdi LiuHui LiYu ZhangZhaohui Wang
作者单位: 1The Affiliated Qingdao Hiser Hospital of Qingdao University, Qingdao, Shandong, China
刊名: Life Sciences, 2020, Vol.247
来源数据库: Elsevier Journal
DOI: 10.1016/j.lfs.2020.117425
关键词: AmentoflavoneAutophagyFerroptosisGlioma
英文摘要: Abstract(#br)Aims(#br)Glioma is the most common type of malignant tumor of the nervous system, and aggressiveness and recurrence are major obstacles for treatment. This study is designed to explore the effects of amentoflavone (AF) on glioma, and to investigate the underlying mechanism of the anti-cancer activities of AF.(#br)Methods(#br)Cell morphology was recorded under microscopy. Cell viability and cell death ratio were determined by CCK-8 assay and lactate dehydrogenase (LDH) release assay, respectively. Cell cycle progression was assessed by flow cytometry. The levels of iron, MDA (malondialdehyde), lipid ROS, and GSH (reduced glutathione) were assessed by ELISA kit. The cycle-related proteins, ferroptosis-related protein, autophagy-related protein, and the phosphorylation of AMPK,...
全文获取路径: Elsevier  (合作)
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影响因子:2.555 (2012)

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关键词翻译
关键词翻译
  • glioma 神经胶质瘤
  • autophagy 自体消瘦
  • dependent 从属的
  • triggering 起动
  • proliferation 增生
  • human 人的
  • death 
  • through 经过