Maternal vitamin D status during pregnancy and offspring risk of childhood/adolescent depression: Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
妊娠期母体维生素D状况及儿童期/青春期抑郁的子代风险:来自父母子女Avon纵向研究( ALSPAC )的结果。
作者: Min-Jung WangErin C. DunnOlivia I. OkerekePeter KraftYiwen ZhuJordan W. Smoller
作者单位: 1Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA
2Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
3Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
4Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA
5Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA
6Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA
7Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA
刊名: Journal of Affective Disorders, 2020, Vol.265 , pp.255-262
来源数据库: Elsevier Journal
DOI: 10.1016/j.jad.2020.01.005
关键词: Vitamin DPolygenic riskGene-environment interactionsDepressionEpidemiologyALSPAC
原始语种摘要: Abstract(#br)Background(#br)Low maternal vitamin D levels [serum 25-hydroxyvitamin D (25(OH)D)] during pregnancy have been linked to offspring neuropsychiatric outcomes such as schizophrenia and autism, but studies on depression are lacking. We examined the association between maternal vitamin D status during pregnancy and offspring depression during childhood and adolescence and investigated whether any associations were modified by offspring genetic risk for depression.(#br)Methods(#br)Mother-singleton birth offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC) that had maternal 25(OH)D measurements, offspring genetic data, and offspring depression measures collected in childhood (mean age=10.6 years; n = 2938) and/or adolescence (mean age=13.8 years; n = 2485)...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:3.295 (2012)

×
关键词翻译
关键词翻译
  • offspring 后代
  • depression 低地
  • vitamin 维生素
  • pregnancy 妊娠
  • status 状态
  • childhood 幼年
  • adolescent 青年
  • maternal 母的
  • during 在的期间
  • genetic 遗传的