Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer
Convallatoxin通过JAK2 / STAT3 ( T705 )和mTOR / STAT3 ( S727 )信号通路之间的串扰,促进细胞凋亡,抑制增殖和血管生成
作者: Zhi Hong ZhangMing Yue LiZhe WangHong Xiang ZuoJing Ying WangYue XingChenghua JinGuanghua XuLianxun PiaoHongxin PiaoJuan MaXuejun Jin
作者单位: 1Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Molecular Medicine Research Center, Ministry of education, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China
2Yanbian University Affiliated Hospital/Liver Diseases Branch, China
刊名: Phytomedicine, 2020, Vol.68
来源数据库: Elsevier Journal
DOI: 10.1016/j.phymed.2020.153172
关键词: ConvallatoxinSTAT3SurvivalProliferationAngiogenesisColorectal cancer
原始语种摘要: Abstract(#br)Background(#br)Aberrant activation of STAT3 is frequently encountered and promotes survival, cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin, triterpenoid ingredient, exhibits anticancer pharmacological properties.(#br)Purpose(#br)In this work, we investigated the anticancer potential of convallatoxin and explored whether convallatoxin mediates its effect through interference with the STAT3 activation in colorectal cancer cells.(#br)Methods(#br)In vitro, the underlying mechanisms of convallatoxin at inhibiting STAT3 activation were investigated by homology modeling and molecular docking, luciferase reporter assay, MTT assay, RT-PCR, Western blotting and immunofluorescence assays. Changes in cellular proliferation, apoptosis,...
全文获取路径: Elsevier  (合作)
影响因子:2.972 (2012)

  • convallatoxin 铃兰毒苷
  • STAT 静止的
  • angiogenesis 血管生成
  • colorectal 结肠直肠的
  • cancer 癌症
  • triterpenoid 三萜系化合物
  • antitumor 抗癌的
  • signaling 发信号
  • murine 鼠灰色
  • survival 生存