Synthesis, antibacterial evaluation, Crystal Structure and Hirshfeld surface analysis of a new 2-Benzylsulfanyl-3-(4-fluoro-phenyl)-6-methyl-3 H -quinazolin-4-one
作者: Mohammed H. Geesi
作者单位: 1Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia
刊名: Journal of Molecular Structure, 2020, Vol.1208
来源数据库: Elsevier Journal
DOI: 10.1016/j.molstruc.2020.127894
关键词: 2-Benzylsulfanyl-3-(4-fluoro-phenyl)-6-methyl-3H-quinazolin-4-oneSynthesisAnti-bacterialCrystal structureHirshfeld surface analysisΠ-π stacking interactions
英文摘要: Abstract(#br)An efficient strategy to access a new 2-Benzylsulfanyl-3-(4-fluoro-phenyl)-6-methyl-3 H -quinazolin-4-one was investigated. The targeted derivative was synthesized by the S-arylation method, the remarkable features of which are a simple procedure and high conversion with short reaction time. The resultant derivative was assessed against bacterial strains. An empirical formula (C 22 H 17 F N 2 O S), system (orthorhombic), space group (P2 1 2 1 2 1 ), unit parameters cell ( a = 5.187 (5) Å, b = 15.754 (5) Å, c = 22.958 (5) Å), volume (1876.0 (19) Å 3 ), Z = = 4, and temperature (293 (2) K) were utilised. A single crystal structure was solved and refined to ( R = 0.0466, w R = 0.1203). The non-hydrogen atoms were refined anisotropically, and the hydrogen atoms were placed...
全文获取路径: Elsevier  (合作)
影响因子:1.404 (2012)

  • antibacterial 抗细菌的
  • analysis 分析
  • evaluation 评价
  • surface