Marked Prognostic Impact of Minimal Lymphatic Tumor Spread in Prostate Cancer
作者: Waldemar WilczakCorinna WittmerTill ClauditzSarah MinnerStefan SteurerFranziska BüscheckTill KrechMaximilian LennartzLuisa HarmsDiane LeleuMarc AhrensSebastian IngwerthChristian T. GüntherChristina KoopRonald SimonFrank JacobsenMaria C. TsourlakisViktoria ChiricoDoris HöflmayerEik VettorazziAlexander HaeseThomas SteuberGeorg SalomonUwe MichlLars BudäusDerya TilkiImke ThederanChristoph FrauneCosima GöbelMarie-Christine HenrichManuela JuhnkeKathari
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Martini-Clinic Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3Department of Urology, Section for Translational Prostate Cancer Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
4Bundeswehr Krankenhaus, Lesserstraße, Hamburg, Germany
5Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
6Department of Pathology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia
刊名: European Urology, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.eururo.2018.05.034
关键词: Lymphatic invasionNodal metastasisPrognosisProstate cancerQuantitative Gleason score
原始语种摘要: Abstract(#br)Background(#br)Nodal metastasis (N1) is a strong prognostic parameter in prostate cancer; however, lymph node evaluation is always incomplete.(#br)Objective(#br)To study the prognostic value of lymphatic invasion (L1) and whether it might complement or even replace lymph node analysis in clinical practice.(#br)Design, setting, and participants(#br)Retrospective analysis of pathological and clinical data from 14 528 consecutive patients.(#br)Intervention(#br)Radical prostatectomy.(#br)Outcome measurements and statistical analysis(#br)The impact of L1 and N1 on patient prognosis was measured with time to biochemical recurrence as the primary endpoint.(#br)Results and limitations(#br)Nodal metastases were found in 1602 (12%) of 13 070 patients with lymph node dissection. L1 was...
全文获取路径: Elsevier  (合作)
影响因子:10.476 (2012)

  • lymphatic 淋巴的
  • prostate 前列腺
  • recurrence 循环
  • prognostic 预测的
  • prognosis 预报
  • PSA 被保护的存储器地址
  • preoperative 操作前的
  • unfavorable 不利
  • unequivocal 不容置疑
  • Cancer 巨蟹座