Peripapillary Sclera Architecture Revisited: A Tangential Fiber Model and its Biomechanical Implications
作者: Andrew P. VoorheesNing-Jiun JanYi HuaBin YangIan A. Sigal
作者单位: 1Department of Ophthalmology, University of Pittsburgh School of Medicine, USA
2Department of Bioengineering, Swanson School of Engineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
刊名: Acta Biomaterialia, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2018.08.020
关键词: BiomechanicsOptic nerve headPeripapillary scleraCollagen architecture
英文摘要: Abstract(#br)The collagen fiber architecture of the peripapillary sclera (PPS), which surrounds the scleral canal, is a critical factor in determining the mechanical response of the optic nerve head (ONH) to variations in intraocular pressure (IOP). Experimental and clinical evidence point to IOP-induced deformations within the scleral canal as important contributing factors of glaucomatous neural tissue damage and consequent vision loss. Hence, it is imperative to understand PPS architecture and biomechanics. Current consensus is that the fibers of the PPS form a closed ring around the canal to support the delicate neural tissues within. We propose an alternative fiber architecture for the PPS, in which the scleral canal is supported primarily by long-running fibers oriented tangentially...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)

  • sclera 巩膜
  • nerve 叶脉
  • architecture 构造
  • Collagen 胶原质