Adiponectin Enhances Human Keratinocyte Lipid Synthesis via SIRT1 and Nuclear Hormone Receptor Signaling
作者: Seung-Phil HongHee-Seok SeoKyong-Oh ShinKyungho ParkByung Cheol ParkMyung Hwa KimMyungjin ParkChang-Deok KimSeong Jun Seo
作者单位: 1Department of Dermatology, College of Medicine, Dankook University, Cheonan, Korea
2Department of Food Science and Nutrition, and Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Korea
3Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea
4Department of Dermatology, Chung-Ang University Hospital, Seoul, Korea
刊名: Journal of Investigative Dermatology, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.jid.2018.08.032
英文摘要: Adiponectin is known to have beneficial effects on lipid and insulin metabolism, wound healing, and cellular senescence, but its effect on skin barrier formation remains unknown. We investigated the effects of adiponectin on keratinocyte lipid synthesis with respect to skin barrier function. Lipid staining revealed an adiponectin-mediated increase in keratinocyte intracellular and reconstructed epidermal lipid content. Moreover, significant increases in the levels of ceramide and its downstream metabolites (sphingosine and sphingosine-1-phosphate) following adiponectin stimulation were detected using liquid chromatography–mass spectrometry. Expression levels of keratinocyte differentiation markers were also increased. Adiponectin also increased expression of lipid biosynthesis enzymes...
全文获取路径: Elsevier  (合作)
影响因子:6.193 (2012)