Clinical features and the molecular biomarkers of olfactory neuroblastoma
作者: Xiaolin PengYao LiuXin PengZhengming WangZhe ZhangYuling QiuMeihua JinRan WangDexin Kong
作者单位: 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
2Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
3Department of Otorhinolaryngology Head and Neck Surgery, Tianjin first central hospital, Tianjin 300192, China
刊名: Pathology - Research and Practice, 2018, Vol.214 (8), pp.1123-1129
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2018.06.002
关键词: Olfactory neuroblastomaClinical featureAktErkStat3
原始语种摘要: Abstract(#br)Olfactory neuroblastoma (ONB) is a kind of rare and complex head and neck tumor. The reports on this field are very scarce due to the low morbidity. Here, we summarized the clinical features and prognosis of ONB through analysis of 10 cases, and determined the phosphorylation status of some molecules known to be involved in carcinogesis such as Akt, Erk, Stat3 and Stat5 in ONB tissue. Ten ONB patients were recruited in this study, 6 male and 4 female, ranging from 26 to 66 years old. In the 10 cases, 6 were diagnosed as late T stage (T 3 /T 4 ), 6 were at late Kadish stage (C/D) and 3 were at high Hyams grade (Ⅲ), which indicated a poorer prognosis. Patient characteristics–gender and tumor features were evaluated with respect to the overall survival (OS) through univariate...
全文获取路径: Elsevier  (合作)
影响因子:1.213 (2012)

  • neuroblastoma 成神经细胞瘤
  • prognosis 预报
  • female 女性的
  • features 特征
  • grade 品位
  • stage 
  • survival 生存
  • combined 组合
  • gender 性别
  • potential