Insufficient harmonization of antibiotics assays – Polish experience with an external quality assessment program in the years 2011–2018
作者: Robert KowalskiAgnieszka ĆwiklińskaMarcin LizakowskiBarbara Kortas-StempakGabriela BednarczukAleksandra FijałkowskaPiotr PikulKrzysztof Lewandowski
作者单位: 1Department of Monitored Therapy and Pharmacogenetics, Medical University of Gdansk, Debinki 7, 80-210 Gdansk, Poland
2Department of Clinical Chemistry, Medical University of Gdansk, Poland
3SOWA-med, Gdansk, Poland
刊名: Clinical Biochemistry, 2019, Vol.66 , pp.91-94
来源数据库: Elsevier Journal
DOI: 10.1016/j.clinbiochem.2019.02.001
关键词: External quality assessmentGentamycinHarmonizationTherapeutic drug monitoringVancomycin
英文摘要: Abstract(#br)Introduction(#br)Treatment with vancomycin and gentamycin requires strict monitoring of its serum concentration for proper dosage optimization. This study aimed to assess the quality and the harmonization of antibiotics assays in Polish laboratories.(#br)Materials and methods(#br)413 results of vancomycin and 148 results of gentamycin assays obtained from Polish laboratories in 30 international external quality assessment (EQA) surveys carried out from March 2011 to May 2018 were analyzed.(#br)Results(#br)Interlaboratory robust coefficients of variation (rCVs) in particular surveys comprised between 1.3 and 47.2% for vancomycin, and between 1.8 and 34.2% for gentamycin. The percentage of the results with the difference above acceptable limit ±10% from the target value...
全文获取路径: Elsevier  (合作)
影响因子:2.45 (2012)

  • 抗生物质 程序
  • harmonization 协调
  • quality 品质
  • external 外部的
  • years 年代
  • assessment 评价
  • monitoring 监视
  • experience 体验
  • program 程序
  • antibiotics 程序