Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia
作者: Magdalena A. ZabielskaJan AdamusRobert KowalskiJerzy GebickiEwa M. SlominskaZain KhalpeyRyszard T. Smolenski
作者单位: 1Department of Biochemistry, Medical University of Gdansk, Gdańsk, Poland
2Department of Physiology, Medical University of Gdansk, Gdańsk, Poland
3Institute of Applied Radiation Chemistry, Technical University of Lodz, Łódź, Poland
4Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdansk, Gdańsk, Poland
5Department of Surgery, Division of Cardiothoracic Surgery, University of Arizona, College of Medicine, Tuscon, USA
刊名: Pharmacological Reports, 2018, Vol.70 (2), pp.378-384
来源数据库: Elsevier Journal
DOI: 10.1016/j.pharep.2017.09.011
关键词: N-1-methylnicotinamide (MNA) salt of pyruvateCardiac hypoxiaMyocardial infarctionApolipoprotein e (ApoE)Low- density lipoprotein receptor (LDLr)
原始语种摘要: Abstract(#br)Background(#br)Pyruvate improves contractility of normal, hypoxic, and post-ischemic myocardium. However, sodium overload is a major problem with its therapeutic application if sodium pyruvate is used. Development of alternative forms such as N-1-methylnicotinamide (MNA) pyruvate may help to overcome this problem. The aim of the study was to investigate the effect of MNA pyruvate in a murine model of cardiac ischemia.(#br)Methods(#br)Seven month old male ApoE −/− LDLr −/− mice that develop myocardial infarction when exposed to hypoxic stress, were used in this study. Hypoxia (8% O2 in inspired air) was maintained for 8min and was followed by reoxygenation (21% O2 in inspired air). Four groups of mice were treated 10min before the hypoxic...
全文获取路径: Elsevier  (合作)
影响因子:1.965 (2012)

  • pyruvate 内酮酸盐
  • hypoxia 氧过少
  • hypoxic 含氧量低的
  • lipoprotein 脂蛋白
  • hypernatremia 血钠过多
  • cardiac 贲门
  • sodium 
  • infarction 梗塞
  • troponin 肌钙蛋白
  • myocardial 心肌的