βIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer
作者: Andrea HinschAref ChakerChristian BurdelskiChristina KoopMaria Christina TsourlakisStefan SteurerMichael RinkTill Simon EichenauerWaldemar WilczakCorinna WittmerMargit FischRonald SimonGuido SauterFranziska BüschekTill ClauditzSarah MinnerFrank Jacobsen
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
2General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
3Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
刊名: Human Pathology, 2017, Vol.61 , pp.210-220
来源数据库: Elsevier Journal
DOI: 10.1016/j.humpath.2016.11.005
关键词: TUBB3TubulinBladder cancerImmunochemistryPrognosis
英文摘要: Summary(#br)Development of genetic instability is a hallmark of tumor progression. Type III β -tubulin (TUBB3) is a component of microtubules involved in chromosome segregation. Its overexpression has been linked to adverse features of urinary bladder cancer. To investigate the role of TUBB3 for development of genetic instability, we compared TUBB3 expression with histopathological features and surrogate markers of genetic instability and tumor aggressiveness; copy number changes of HER2 , TOP2A , CCND1 , RAF1 , and FGFR1 ; nuclear accumulation of p53, and cell proliferation in a tissue microarray (TMA) with more than 700 bladder cancers. TUBB3 expression was linked to high-grade and advanced-stage cancers ( P <.0001), rapid cell proliferation ( P...
全文获取路径: Elsevier  (合作)
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影响因子:2.843 (2012)

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关键词翻译
关键词翻译
  • bladder 膀胱
  • urinary 尿的
  • aggressive 侵蚀的
  • instability 不稳定性
  • cancer 癌症
  • genetic 遗传的
  • features 特征
  • tubulin 微管蛋白
  • linked 连接的
  • tumor 肿胀