Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice
作者: Zisheng ChenDacheng YangXinwei JiangLingmin TianJianxia SunDongbo TianWeibin Bai
作者单位: 1Department of Respiratory Medicine, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, China
2Department of Food Science and Engineering, College of Science and Technology, Jinan University, Guangzhou, China
3Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China
刊名: Food and Chemical Toxicology, 2019, Vol.130 , pp.1-11
来源数据库: Elsevier Journal
DOI: 10.1016/j.fct.2019.04.054
关键词: Non-small cell lung cancerCudrania tricuspidataKras mutationFinal-2Autophagy
英文摘要: Abstract(#br)Natural products derived from fruits have multiple antitumor potential. However, very few have been developed for clinical therapy, due to the limited efficiency or insufficient study of their mechanism. Since lung cancer is the most common cancer in the world, there is still need to explore novel compounds but their molecular mechanisms remain elusive. In this study, a new compound Final-2 was synthesized. Final-2 exhibited antitumor activity in A549 cells by promoting apoptosis and blocking autophagy. Moreover, Final-2 significantly induced G 0 /G 1 cycle arrest and inhibited cell malignancy. Intracellular molecular targets investigation showed that Final-2 inhibited the Gluts, which resulted in downregulation of glucose metabolism and the oncogene c-Myc and Kras expression...
全文获取路径: Elsevier  (合作)
影响因子:3.01 (2012)

  • nude 无约因
  • adenocarcinoma 腺癌
  • targeted 对准目标的
  • xenograft 异种移植片
  • autophagy 自体消瘦
  • glycolysis 糖解
  • inhibit 禁止
  • apoptosis 细胞死
  • cells 麻风细胞
  • failed 失败