Evaluation of guggulsterone derivatives as novel kidney cell protective agents against cisplatin-induced nephrotoxicity
作者: Dahae LeeTaejung KimKi Hyun KimJungyeob HamTae Su JangKi Sung KangJae Wook Lee
作者单位: 1College of Korean Medicine, Gachon University, Seonngman 13120, Republic of Korea
2School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea
3Natural Constituent Research Center, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea
4Institute of Green Bio Science &Technology, Seoul National University, Pyeong Chang 232-916, Republic of Korea
5Convergent Research Center for Dementia, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea
6Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113 Republic of Korea
刊名: Bioorganic & Medicinal Chemistry Letters, 2017, Vol.27 (14), pp.3156-3161
来源数据库: Elsevier Journal
DOI: 10.1016/j.bmcl.2017.05.033
关键词: GuggulsteroneKidney protectionClick chemistryMAPK
英文摘要: Abstract(#br)Guggulsterone derivatives were prepared using [3+2] click chemistry with aryl and alkyl acetylene. The series of derivatives were evaluated for their cellular protective effects on cisplatin-treated cultured LLC-PK1 kidney epithelial cells. Among the guggulsterone-triazole derivatives, compound 6g, which contains a hydroxyl methyl group, was the most active of all the derivatives. In an additional study, we determined that inhibition of the mitogen-activated protein kinase/caspase-3 signaling cascade by 6g mediates its protective effects against cytotoxicity in cultured LLC-PK1 cells.
全文获取路径: Elsevier  (合作)
影响因子:2.338 (2012)

  • nephrotoxicity 中毒性肾损害
  • cisplatin 顺氯氨铂
  • kidney 肾脏
  • induced 感应的
  • against 反对
  • novel 长篇小说
  • Kidney 
  • protection 保护
  • derivatives 派生物
  • protective 保护的