Integrating Tertiary Gleason 5 Patterns into Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens
作者: Guido SauterTill ClauditzStefan SteurerCorinna WittmerFranziska BüscheckTill KrechFlorian LutzMaximilian LennartzLuisa HarmsLisa LawrenzChristina Möller-KoopRonald SimonFrank JacobsenWaldemar WilczakSarah MinnerMaria Christina TsourlakisViktoria ChiricoSören WeidemannAlexander HaeseThomas SteuberGeorg SalomonMichael MatiuEik VettorazziUwe MichlLars BudäusDerya TilkiImke ThederanDirk PehrkeBurkhard BeyerChristoph FrauneCosima GöbelMarie Heinrich
作者单位: 1Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
2Martini-Klinik, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3Department of Ecoclimatology, Technical University Munich, Munich, Germany
4Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
5Department of Urology, Section for Translational Prostate Cancer Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
刊名: European Urology, 2018, Vol.73 (5), pp.674-683
来源数据库: Elsevier Journal
DOI: 10.1016/j.eururo.2017.01.015
关键词: Prostate cancerGleason scoreQuantitative Gleason gradePrognosis
原始语种摘要: Abstract(#br)Background(#br)Presence of small (tertiary) Gleason 5 pattern is linked to a higher risk of biochemical recurrence in prostate cancer. It is unclear, however, how to integrate small Gleason 5 elements into clinically relevant Gleason grade groups.(#br)Objective(#br)To analyze the prognostic impact of Gleason 5 patterns in prostate cancer and to develop a method for integrating tertiary Gleason 5 patterns into a quantitative Gleason grading system.(#br)Design, setting, and participants(#br)Prostatectomy specimens from 13 261 consecutive patients and of 3295 matched preoperative biopsies were available. Percentages of Gleason 3, 4, and 5 had been recorded for each cancer.(#br)Outcome measurements and statistical analysis:(#br)Results and limitations(#br)Our data demonstrate...
全文获取路径: Elsevier  (合作)
影响因子:10.476 (2012)

  • prostate 前列腺
  • recurrence 循环
  • grading 粒级成层
  • prognosis 预报
  • grade 品位
  • score 得分
  • unfavorable 不利
  • prognostic 预测的
  • quantitative 量的
  • clinically 临床上