Both sphingosine kinase 1 and 2 coordinately regulate cathelicidin antimicrobial peptide production during keratinocyte differentiation
作者: Kyong-Oh ShinKun Pyo KimYunhi ChoMin-Kyung KangYoung-Hee KangYong-Moon LeeHiroko IkushiroMami YokotaTakato YanoSung Jay ChoeEung Ho ChoiChae Jin LimKeedon ParkWalter M. HolleranKyungho ParkYoshikazu Uchida
作者单位: 1College of Pharmacy Chungbuk National University, Cheongju, Korea
2Department of Food Science and Nutrition, Hallym University, Chuncheon, Korea
3Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Korea
4Department of Biochemistry, Faculty of Medicine, Osaka Medical College, Takatsuki, Japan
5Laboratory of Dermatological Physiology, Faculty of Pharmaceutical Sciences, Josai University, Sakado, Japan
6Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea
7Peptide R&D Center, Incospharm Corporation, Daejeon, Korea
8Department of Dermatology, School of Medicine, University of California, San Francisco, USA
9Northern California Institute for Research and Education, Veterans Affairs Medical Center, San Francisco, USA
刊名: Journal of Investigative Dermatology, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.jid.2018.08.015
关键词: Cathelicidin antimicrobial peptideER stressKeratinocyte differentiationSphingosine kinaseSphingosine-1-phosphate
英文摘要: Abstract(#br)The innate immune element, cathelicidin antimicrobial peptide (CAMP), is vital in the formation of the antimicrobial barrier in skin. CAMP production is increased during epidermal differentiation and enriched in the stratum corneum. We recently identified an endoplasmic reticulum (ER) stress-mediated sphingosine-1-phosphate (S1P)- dependent mechanism of CAMP synthesis. Interestingly, in this study, we found that S1P synthesized by an isoform of sphingosine kinase (SPHK), SPHK1, serves as a signal for CAMP synthesis; and conversely, another isoform SPHK2 likely has a suppressor role or no role in CAMP production. Pertinently, prior studies showed that physiological ER stress is essential for normal epidermal differentiation. We here demonstrate that: increased ER stress is...
全文获取路径: Elsevier  (合作)
影响因子:6.193 (2012)

  • keratinocyte 角化细胞
  • sphingosine 鞘氨醇
  • antimicrobial 杀菌剂
  • regulate 控制
  • peptide 
  • kinase 激酶
  • during 在的期间
  • production 生产