Toxic effects of zearalenone on gametogenesis and embryonic development: A molecular point of review
作者: Dacheng YangXinwei JiangJianxia SunXia LiXusheng LiRui JiaoZiyao PengYuqi LiWeibin Bai
作者单位: 1Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou 510632, PR China
2School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510090, PR China
刊名: Food and Chemical Toxicology, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.fct.2018.06.003
关键词: ZearalenoneGametogenesisEmbryonic developmentDamageMechanisms
英文摘要: Abstract(#br)Zearalenone is commonly generated from moldy cereal grain, which is toxic to the development of gametogenesis and embryo in human and animals. The zearalenone-induced reproductive damage is mainly attributed to four mechanisms. Firstly, zearalenone as an oestrogen-like compound binds to estrogen receptor and causes damage to germ cells and testicular structure. Secondly, zearalenone disrupts the blood-testis barrier, and causes the damage to germ cells. Thirdly, zearalenone elevates oxidative stress, which increases the production of lipid peroxides, and results in the damage to the antioxidant defense system. Fourth, zearalenone increases DNA damage and promotes cells apoptosis. In addition, Zearalenone induces inflammatory reactions and leads to the disorders of...
全文获取路径: Elsevier  (合作)
影响因子:3.01 (2012)

  • zearalenone 玉米赤霉烯酮
  • development 开发
  • gametogenesis 配子形成
  • review 复审
  • molecular 分子的
  • effects 海员自身物品
  • embryonic 胚的
  • point