p , p ′-Methoxyl-diphenyl diselenide-loaded polymeric nanocapsules as a novel approach to inflammatory pain treatment: Behavioral, biochemistry and molecular evidence
作者: Marcel Henrique Marcondes SariVanessa Angonesi ZborowskiLuana Mota FerreiraNatália Silva JardimAllanna Valentini BarbieriLetícia CruzCristina Wayne Nogueira
作者单位: 1Programa de Pós-graduação em Bioquímica Toxicológica, Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Departamento de Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil
2Programa de Pós-graduação em Ciências Farmacêuticas, Laboratório de Tecnologia Farmacêutica, Departamento de Farmácia Industrial, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil
刊名: European Journal of Pharmaceutical Sciences, 2018, Vol.111 , pp.38-45
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejps.2017.09.030
关键词: OrganoseleniumNanoparticlesInflammationMice
英文摘要: Abstract(#br)The current study investigated the effect of organoselenium compound p , p ′-methoxyl-diphenyl diselenide [(OMePhSe) 2 ], free or incorporated into nanocapsules, on behavioral, biochemical and molecular alterations in an inflammatory pain model induced by complete Freund's adjuvant (CFA). Male Swiss mice received an intraplantar injection of CFA in the hindpaw and 24 h later they were treated via the intragastric route with a single (OMePhSe) 2 administration, in its free form (dissolved in canola oil) or (OMePhSe) 2 NC. The anti-hypernociceptive time- and dose-response curves were carried out using the von Frey hair test. Biochemical and histological parameters were determined in samples of injected paws and those of cerebral contralateral cortex were collected to determine...
全文获取路径: Elsevier  (合作)
影响因子:2.987 (2012)

  • diphenyl 联二苯
  • diselenide 联硒化物
  • polymeric 聚合的
  • loaded 加负荷的
  • treatment 处理
  • biochemistry 生化学
  • molecular 分子的
  • approach 
  • inflammatory 激怒的
  • evidence