Applicability of the grip strength and automated von Frey tactile sensitivity tests in the mouse photothrombotic model of stroke
作者: Faisal F. AlamriAbdullah Al ShoyaibAbbie BiggersSrinidhi JayaramanJosée GuindonVardan T. Karamyan
作者单位: 1Department of Pharmaceutical Sciences, School of Pharmacy, TTUHSC, United States
2Department of Pharmacology and Neuroscience, School of Medicine, TTUHSC, United States
3Center for Blood Brain Barrier Research, School of Pharmacy, TTUHSC, United States
刊名: Behavioural Brain Research, 2018, Vol.336 , pp.250-255
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbr.2017.09.008
关键词: PhotothrombosisStroke recoverySensorimotor testMechanical sensitivityDigital electronic von FreyAnesthesiometer
原始语种摘要: Abstract(#br)Improvement of impaired neurological function(s) is a primary endpoint in experimental stroke recovery studies, making the choice and nature of the functional tests crucial for proper execution and interpretation of such studies. Currently, there are a limited number of neurological tests which reliably evaluate functional deficit in mice over a long period of time after stroke. In this study, we evaluated the applicability of forepaw grip strength and automated von Frey tactile sensitivity tests to assess forelimb dysfunction in mice following photothrombosis in the sensorimotor cortex, and compared them with two well-established tests, grid-walking and cylinder, for up to 21days after stroke. Our results indicate that the length of time required to...
全文获取路径: Elsevier  (合作)
影响因子:3.327 (2012)

  • stroke 笔划
  • mouse 小鼠
  • functional 功能的
  • evaluate 求...的值
  • tactile 触觉的
  • automated 自动
  • sensitivity 灵敏度
  • together 共同
  • proper 合适的
  • sensitive 灵敏的