CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion
作者: Na DingRongxin LiWenhao ShiCui He
作者单位: 1Clinical Medical College, Weifang Medical University, No.7166 Baotong Road West, Weifang 261053, Shandong, China
2Department of Pharmacy, Affiliated Hospital of Weifang Medical University, No.2428 Yuhe Road, Weifang 261031, Shandong, China
3Clinical Medical College, Binzhou Medical University, No.346 Guanhai Road, Yantai 264003, Shandong, China
4Department of Gastrointestinal Surgery, Affiliated Hospital of Weifang Medical University, No.2428 Yuhe Road, Weifang 261031, Shandong, China
刊名: Gene, 2018, Vol.674 , pp.80-86
来源数据库: Elsevier Journal
DOI: 10.1016/j.gene.2018.06.067
关键词: CENPIBiomarkerMetastasisEMTColorectal cancer
英文摘要: Abstract(#br)Centromere protein I (CENPI),an important member of centromere protein family, has been suggest to serve as a oncogene in breast cancer, but the clinical significance and biological function of CENPI in colorectal cancer (CRC) is still unclear. In our results, we found CENPI was overexpressed in CRC tissues and cells, and associated with clinical stage, tumor depth, lymph node metastasis, distant metastasis and differentiation in CRC patients. However, there was no significant association between CENPI protein expression and overall survival time in colon cancer patients and rectal cancer patients through analyzing TCGA survival data. Moreover, CENPI mRNA and protein were increased in metastatic lymph nodes compared with primary CRC tissues. Down-regulation of CENPI...
全文获取路径: Elsevier  (合作)
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影响因子:2.196 (2012)

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关键词翻译
关键词翻译
  • migration 迁移
  • cancer 癌症
  • EMT EMergency Treatment
  • colorectal 结肠直肠的
  • invasion 侵入