Role of NMDA receptor GluN2D subunit in the antidepressant effects of enantiomers of ketamine
作者: Soichiro IdeYuiko IkekuboMasayoshi MishinaKenji HashimotoKazutaka Ikeda
作者单位: 1Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan
2Brain Science Laboratory, The Research Organization of Science and Technology, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan
3Center for Forensic Mental Health, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan
刊名: Journal of Pharmacological Sciences, 2017, Vol.135 (3), pp.138-140
来源数据库: Elsevier Journal
DOI: 10.1016/j.jphs.2017.11.001
关键词: KetamineDepressionGluN2D
英文摘要: Abstract(#br)We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N -methyl- d -aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted significant antidepressant effects on restraint stress-induced depression in both wildtype and GluN2D-KO mice. The antidepressant effects of ( RS )-ketamine and ( S )-ketamine were sustained 96 h after the injection in both wildtype and GluN2D-KO mice, but such sustained antidepressant effects of ( R )-ketamine were only observed in wildtype mice. These data suggest that the GluN2D subunit is critical for the sustained antidepressant effects of ( R )-ketamine.
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:2.15 (2012)

×
关键词翻译
关键词翻译
  • antidepressant 抗抑郁药
  • ketamine 氯胺酮
  • subunit 亚单位
  • receptor 接受体
  • effects 海员自身物品