Measuring longitudinal cognition: Individual tests versus composites
作者: Erin M. JonaitisRebecca L. KoscikLindsay R. ClarkYue MaTobey J. BetthauserSara E. BermanSamantha L. AllisonKimberly D. MuellerBruce P. HermannCarol A. Van HulleBradley T. ChristianBarbara B. BendlinKaj BlennowHenrik ZetterbergCynthia M. CarlssonSanjay AsthanaSterling C. Johnson
作者单位: 1Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
2Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison WI, USA
3Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA
4Department of Communication Sciences and Disorders, University of Wisconsin, Madison, WI, USA
5Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
6Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA
7Department of Psychiatry, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA
8Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
9Clinical Neurochemistry Laboratory, Sahlgrenska University Hospita
刊名: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, Vol.11 , pp.74-84
来源数据库: Elsevier Journal
DOI: 10.1016/j.dadm.2018.11.006
关键词: BiostatisticsLongitudinal data analysisCognitive agingNeuropsychological testsComposite scoresIntraindividual variability
英文摘要: Abstract(#br)Introduction(#br)Longitudinal cohort studies of cognitive aging must confront several sources of within-person variability in scores. In this article, we compare several neuropsychological measures in terms of longitudinal error variance and relationships with biomarker-assessed brain amyloidosis (Aβ).(#br)Methods(#br)Analyses used data from the Wisconsin Registry for Alzheimer's Prevention. We quantified within-person longitudinal variability and age-related trajectories for several global and domain-specific composites and their constituent scores. For a subset with cerebrospinal fluid or amyloid positron emission tomography measures, we examined how Aβ modified cognitive trajectories.(#br)Results(#br)Global and theoretically derived composites exhibited lower...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • cognition 认识
  • longitudinal 纵向的
  • composites 菊科植物
  • versus