Cellular chaining influences biofilm formation and structure in group A Streptococcus
作者: Artur MatysikFoo Kiong HoAlicia Qian Ler TanAnuradha VajjalaKimberly A. Kline
作者单位: 1Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, 60 Nanyang Dr, 637551, Singapore
2School of Biological Sciences, Nanyang Technological University, 60 Nanyang Dr, Singapore, 637551
刊名: Biofilm, 2020, Vol.2
来源数据库: Elsevier Journal
DOI: 10.1016/j.bioflm.2019.100013
关键词: Streptococcus pyogenesBiofilmsChainingAutolysinMur1.2Static biofilm assayGroup A Streptococcus
英文摘要: Abstract(#br)Group A Streptococcal (GAS) biofilm formation is an important pathological feature contributing to the antibiotic tolerance and progression of various GAS infections. Although a number of bacterial factors have been described to promote in vitro GAS biofilm formation, the relevance of in vitro biofilms to host-associated biofilms requires further understanding. In this study, we demonstrate how constituents of the host environment, such as lysozyme and NaCl, can modulate GAS bacterial chain length and, in turn, shape GAS biofilm morphology and structure. Disruption of GAS chains with lysozyme results in biofilms that are more stable. Based on confocal microscopy, we attribute the increase in biofilm stability to a dense and compact three-dimensional structure produced by...
全文获取路径: Elsevier  (合作)

  • biofilm 生物薄膜
  • chaining 链接
  • structure 构造
  • formation 建造
  • group