Cyanidin-3- O -glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage
作者: Xusheng LiZilan YaoDacheng YangXinwei JiangJianxia SunLingmin TianJun HuBiyu WuWeibin Bai
作者单位: 1Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, 510632, PR China
2School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, 510006, PR China
3Department of Human, Nutrition, Food and Animal Science, University of Hawaii at Manoa, Honolulu, HI, 96816, USA
刊名: Journal of Hazardous Materials, 2019
来源数据库: Elsevier Journal
DOI: 10.1016/j.jhazmat.2019.121706
关键词: AnthocyaninCadmiumPubertySpermatogenesisMale infertility
原始语种摘要: Abstract(#br)Cadmium (Cd) is an environmental contaminant found in soil, water, and food, and can cause oxidative stress and male reproductive damage. During puberty, the male reproductive system is very vulnerable to interference, however, the dysregulation of Cd on spermatogenesis in this period is ambiguous. The anthocyanin cyanidin-3- O -glucoside (C3G) is phytochemical rich in plants and fruits and has been shown to have remarkable anti-oxidant activity, making it an ideal nutrient for nutritional intervention. By modeling Cd-induced damage in male pubertal mice and feeding with C3G, we demonstrated that the C3G could rescue the amount and activity of sperm predominantly. Furthermore, C3G showed partial resistance to Cd-induced histone modification during spermiogenesis and prevented...
全文获取路径: Elsevier  (合作)
影响因子:3.925 (2012)

  • spermatogenic 精子发生的
  • glucoside 糖甙
  • pubertal 青春期的
  • oxidative 氧化的
  • damage 损伤
  • infertility 不育
  • puberty 青春期
  • intervention 
  • spermiogenesis 精子形成
  • induced 感应的