Tumor cellular proliferation is associated with enhanced immune checkpoint expression in stage I non–small cell lung cancer
作者: Kyle G. MitchellEdwin R. ParraDavid B. NelsonJiexin ZhangIgnacio I. WistubaJunya FujimotoJack A. RothMara B. AntonoffErin M. CorsiniAra A. VaporciyanWayne L. HofstetterReza J. MehranStephen G. SwisherDavid C. RiceBoris SepesiGarrett L. WalshCarmen BehrensNeda KalhorAnnikka WeissferdtCesar A. MoranJ. Jack Lee
刊名: The Journal of Thoracic and Cardiovascular Surgery, 2019, Vol.158 (3), pp.911-919.e6
来源数据库: Elsevier Journal
DOI: 10.1016/j.jtcvs.2019.04.084
关键词: Non–small cell lung cancerImmune microenvironmentImmune checkpointsKi67
原始语种摘要: Abstract(#br)Objectives(#br)Ki67 is a marker for tumor proliferative activity and is known to have prognostic significance in multiple solid malignancies. We sought to characterize the relationships among Ki67 expression, immune cell infiltration, and immune checkpoint expression in patients with resected non–small cell lung cancer.(#br)Methods(#br)Specimens of patients undergoing resection of stage I to III non–small cell lung cancer (1997-2012) were analyzed using tissue microarrays. Proliferative index was quantified as the percentage of malignant cells expressing Ki67. Checkpoints expressed on malignant cells (programmed death ligand 1, B7H3, B7H4, indoleamine 2,3-dioxygenase 1) and lymphocytes (T-cell immunoglobulin and mucin-domain containing 3, V-domain suppressor of T-cell...
全文获取路径: Elsevier  (合作)

  • expression 表示
  • small 小的
  • checkpoint 检查地点
  • immune 免疫的
  • associated 相关的
  • enhanced 增强
  • cancer 癌症
  • stage 
  • cellular 细胞状的
  • proliferation 增生