Serum levels of proteins involved in amyloid-β clearance are related to cognitive decline and neuroimaging changes in mild cognitive impairment
作者: Shan LiuHideaki SuzukiHitomi ItoTatsumi KorenagaHiroyasu AkatsuKohji MenoKazuhiko Uchida
作者单位: 1Department of Molecular Biological Oncology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
2Department of Neuropsychiatry, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
3Tsukuba Industrial Liaison and Cooperative Research Center, University of Tsukuba, Tsukuba, Ibaraki, Japan
4Research Division, MCBI. Inc., Ibaraki, Japan
5Fukusimura Hospital, Toyohashi, Aichi, Japan
刊名: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019, Vol.11 , pp.85-97
来源数据库: Elsevier Journal
DOI: 10.1016/j.dadm.2018.11.003
关键词: Alzheimer's diseaseBiomarkerComplement proteinMicrogliaNeuroinflammation
英文摘要: Abstract(#br)Introduction(#br)Amyloid-β (Aβ) clearance is important for damage prevention in Alzheimer's disease. We investigated the utility of Aβ clearance proteins as biomarkers for mild cognitive impairment (MCI).(#br)Methods(#br)Serum apolipoprotein (apo) A-I, compliment protein C3 (C3), transthyretin, and cholesterol levels were measured in 273 subjects, and we analyzed the relationship between these levels and brain atrophy and cerebral blood flow in 63 clinically diagnosed mild cognitive impairment, Alzheimer's disease, and nondemented disease control subjects.(#br)Results(#br)ApoA-I and transthyretin levels and the active form of C3:native form of C3 ratio achieved an area under the curve of 0.89 (sensitivity: 83%, specificity: 90%) for detecting late mild cognitive impairment....
全文获取路径: Elsevier  (合作)

  • cognitive 修]认知[识
  • impairment 减损
  • amyloid 淀粉状朊
  • related 有关的
  • clearance 间隙
  • involved 涉及
  • decline 推辞
  • proteins 蛋白质